Table 2.
Relationship between treatment response and clinicopathological factors
| Treatment response | Multi-variates | ||||
|---|---|---|---|---|---|
| CR/PR | SD/PD | P | OR (95%CI) |
P | |
| Age | |||||
| ≦50 | 15 (68.2%) | 7 (31.8%) | 0.844 | 1 | |
| > 50 | 26 (74.3%) | 9 (25.7%) | 0.53 (0.07, 3.65) | 0.520 | |
| Gender | |||||
| male | 39 (70.9%) | 16 (29.1%) | 1.000 | 1 | |
| female | 2 (100%) | 0 (0%) | Indeterminate | 1.000 | |
| Tumor Site | |||||
| oral cavity | 15 (62.5%) | 9 (37.5%) | 0.049* | 1 | |
| oropharynx | 14 (66.7%) | 7 (33.3%) | 1.29 (0.21, 7.70) | 0.778 | |
| hypopharynx/larynx | 12 (100%) | 0 | Indeterminate | 0.998 | |
| Stage | |||||
| IVa | 10 (100%) | 0 (0%) | 0.048* | 1 | |
| IVb | 31 (66.0%) | 16 (34.0%) | Indeterminate | 0.998 | |
| T stage | |||||
| 1/2 | 6 (100%) | 0 (0%) | 0.170 | 1 | |
| 3/4 | 35 (68.6%) | 16 (31.4%) | Indeterminate | 0.999 | |
| N stage | |||||
| negative | 8 (66.7%) | 4 (25.0%) | 0.732 | 1 | |
| positive | 33 (73.3%) | 12 (26.7%) | 0.75 (0.06, 8.54) | 0.818 | |
| Radiation | |||||
| ≦6000 cGy | 14 (70.0%) | 6 (30.0%) | 1.000 | 1 | |
| > 6000 cGy | 27 (75.7%) | 10 (24.3%) | 0.22 (0.02, 2.43) | 0.222 | |
| Alcohol drinking | |||||
| never | 9 (81.8%) | 2 (18.2%) | 0.710 | 1 | 0.120 |
| yes | 32 (69.6%) | 14 (30.4%) | 0.08 (0.004, 1.89) | ||
| Smoking | |||||
| never | 7 (77.8%) | 2 (22.2%) | 1.000 | 1 | |
| yes | 34 (70.8%) | 14 (29.2%) | 2.97 (0.10, 86.59) | 0.526 | |
| Betel nuts | |||||
| never | 16 (80.0%) | 4 (20.0%) | 0.491 | 1 | |
| yes | 25 (67.6%) | 12 (32.4%) | 0.38 (0.03, 4.55) | 0.452 | |
| ERCC1 | |||||
| low expression | 28 (90.3%) | 3 (9.7%) | 0.002* | 1 | |
| high expression | 13 (20.0%) | 13 (50.0%) | 0.07 (0.009, 055). | 0.012* | |
CR, complete response; PR, partial response; SD, stable disease; PD, disease progression; RTO, radiotherapy; OR, odds ratio; CI, confidence interval