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. 2011 Apr 7;7(4):e1002030. doi: 10.1371/journal.pcbi.1002030

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Engelberg et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Percentage of cysts that have single (solid circle) or multiple (open circle) lumens. (B) Percentage of SLSL (single-layer, single-lumen) cysts. Blue: in vitro data for 20 cysts taken each day for ten days. Red: in silico data for 50 cysts using parameters values from Table 2. Black: mean and standard deviation for “normal” MDCK cysts observed by Zheng et al. [6] as described in the text. Solid lines represent continuous growth of ISMA cysts. Dotted lines represent discrete growth of MDCK cysts.