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. 2011 Apr 7;7(4):e1001330. doi: 10.1371/journal.ppat.1001330

Figure 5. Effect of penitrem A and emodepside on nematode locomotion.

Figure 5

(A) Migration of infective A. caninum larvae (relative to negative control without vehicle) through a 20 µm precision sieve after incubation in different concentrations of emodepside in presence or absence of penitrem A. (B) Body bend activity of C. elegans (relative to negative control without vehicle). (A, B) Negative control (black bar), without vehicle or substance; vehicle control (light grey bars), with 28 mM DMSO, 170 mM ethanol, and the indicated emodepside concentrations; 1 µM penitrem A (dark grey bars), with 1 µM penitrem A, 170 mM ethanol and the indicated emodepside concentrations. Error bars represent standard deviations. Asterisks mark a significant difference between vehicle controls and the experiments with 1 µM penitrem A at the same emodepside concentration (*** p<0.001) determined by One-Way-ANOVA followed by a Tukey's pairwise comparison.