Table 1. A summary of the pharmacological response to emodepside in transgenic lines expressing either C. elegans or parasite slo-1 under the control of C. elegans-derived promoters.

Strain/line*	N2#	Cel-snb-1::Aca-slo-1	N2	Cel-snb-1::Con-slo-1
Hill slope	-0.74	-0.85	-0.83	-0.53
95% confidence interval	-0.94 to -0.54	-1.32 to -0.37	-1.07 to -0.58	-0.82 to -0.23
EC50 [µM]	0.1442	0.1972	0.1285	0.2397
95% confidence interval [µM]	0.11 to 0.2	0.01 to 0.42	0 to 0.19	0 to 0.82
Bottom [%]	0	45.67	2.0	34.36
95% confidence interval [%]	0.0 to 7.42	36.36 to 54.99	0.0 to 9.96	16.80 to 51.93
R2	0.96	0.83	0.95	0.76
p (4 parameters)x	<0.0001		< 0.0001
p (EC50)x	0.4367		0.3458
p (bottom)x	0.0012		0.0263

The data given are the Hill slope, EC₅₀ and bottom values for the four parameter logistic inhibition curves with 95% confidence intervals. Top values were always close to 100% due to normalization to the highest absolute value in each data set. The values were determined from pooled data for 3 experiments.

#: For both A. caninum experiments, the same N2 control was used.

*Since all curves were significantly different from slo-1(js379) (p<0.0001), which did not show a concentration-dependent response at all, this comparison is not listed here.

^xComparisons were done for all four parameters of a concentration-response-curves (Hill slope, EC₅₀, top and bottom). If significant differences were obtained with this calculation, separate comparisons for EC₅₀ and bottom followed.