Table 1. Delphi panel events.

Clinical events	Definition
Ischemic events
Transient ischemic attack	Transient ischemic event q 24 hrs duration
Ischemic stroke with no symptom at 7 days	Defined by a modified Rankin scale of 0–1
Ischemic stroke with slight disability at 7 days	Defined by a modified Rankin scale of 2
Ischemic stroke with moderate disability at 7 days	Defined by a modified Rankin scale of 3
Ischemic stroke with severe disability at 7 days	Defined by a modified Rankin scale of 4–5
Limb ischemia not requiring heparin or intervention	Brief (q 24 hrs) episode of ischemia managed non surgically and without permanent deficit
Limb ischemia requiring heparin or intervention	Recurring or prolonged (> 24 hrs) requiring medical or surgical intervention
Limb ischemia requiring amputation*	Life-threatening, disabling limb ischemia requiring end organ damage (i.e., limb loss)
Increased level of troponin	Without new Q wave or heart failure
Non-fatal myocardial infarction without heart failure	Killip 1
Non-fatal myocardial infarction with heart failure	Killip ≥2
Under-popliteal deep venous thrombosis	Under-popliteal deep venous thrombosis
Deep venous thrombosis with iliac extension	Deep venous thrombosis with iliac extension
Venous thrombosis of the pectoral limb	Venous thrombosis of the pectoral limb
Venous thrombosis other	Venous thrombosis other
Pulmonary embolism	Pulmonary embolism
Massive pulmonary embolism	Clinical or echographical acute pulmonary heart and/or impact on hepatic biology and/or more than half obstruction at angiography
Hemorrhagic events
Intracerebral hemorrhage with no symptom at 7 days	Defined by a modified Rankin scale of 0–1
Intracerebral hemorrhage with slight disability at 7 days	Defined by a modified Rankin scale of 2
Intracerebral hemorrhage with moderate disability at 7 days	Defined by a modified Rankin scale of 3
Intracerebral hemorrhage with severe disability at 7 days	Defined by a modified Rankin scale of 4–5
Bleeding with increased length of stay	Mild bleeding not requiring intervention other than iron supplements
Bleeding requiring redo surgery or endoscopic sclerosis
Bleeding requiring both redo surgery and interventions to maintain cardiac output	Bleeding with life-threatening consequences requiring urgent and major interventions
Bleeding requiring transfusion of 3 U or more packed red blood cells	Bleeding requiring transfusion of 3 U or more packed red blood cells
Bleeding requiring both transfusion of 3 U or more packed red blood cells and interventions to increase cardiac output	Bleeding with life-threatening consequences requiring urgent and major interventions
Intra or retroperitoneal bleeding	Intra or retroperitoneal bleeding
Intra or retroperitoneal bleeding requiring interventions to maintain cardiac output	Bleeding with life-threatening consequences requiring urgent and major interventions

Mesenteric ischaemia is considered as peripheral ischemia and then classified as “Life-threatening, disabling limb ischemia requiring end organ damage (i.e., limb loss)” and thus with limb ischemia requiring amputation.