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. 2011 Apr 7;6(4):e18447. doi: 10.1371/journal.pone.0018447

Figure 6. Inhibition of IKKβ sensitizes MCF-7 cells to IR.

Figure 6

(A) Clonogenic survival of vector- or IKKα and/or IKKβ shRNA-transfected MCF7 cells after exposure to 0, 1, 2 and 3 Gy IR. (B) Clonogenic survival of MCF-7 cells and MCF-7/IKKβ (-) cells transfected with vector, wild-type (WT), kinase dead (K44M), or a constitutively active form (SSEE) IKKβ after exposure to 0, 1, 2 and 3 Gy IR. (C) Clonogenic survival of vehicle- or 2.5 µM BMS-345541 (BMS)-pretreated MCF-7 cells after exposure to 0, 1, 2 and 3 Gy IR. The data are expressed as mean ± SE (n = 3) of survival fraction compared to un-irradiated MCF-7 cells. *** p<0.001.