Table 1. Gene ontology enrichment of the putative gene targets of ten upregulated GK islet miRNAs.
Functional Group 1 | ||||
Gene ontology (GO) term | Gene count | Fold Enrichment | P-value | Bonferroni corrected |
GO:0015031∼protein transport | 87 | 2.1 | 2.78E-11 | 6.86E-08 |
GO:0046907∼intracellular transport | 96 | 2.0 | 8.04E-11 | 1.98E-07 |
GO:0006886∼intracellular protein transport | 63 | 2.2 | 8.18E-09 | 2.02E-05 |
1342 glucose-regulated putative gene targets (listed in Table S1) of ten upregulated miRNAs in GK rat islets yielded two statistically-significant clustering of Gene Ontology (GO) terms characterising transport and secretory processes.