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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Biochem Pharmacol. 2011 Mar 1;81(9):1152–1163. doi: 10.1016/j.bcp.2011.02.015

Figure 4. EGCG selectively prevented LPS-induced elevation of cellular HMGB1 levels.

Figure 4

Primary murine peritoneal macrophages were stimulated with LPS in the absence or presence of EGCG at indicated regimens, and assayed for cellular levels of HMGB1 (Panel A, B) or other 62 cytokines (Panel C) by Western blotting analysis or Cytokine Antibody Arrays, respectively. A, B). EGCG dose-dependently prevented LPS-induced increase of cellular HMGB1 levels. C). EGCG did not affect LPS-induced elevation of most other cytokines. Panel C-I denotes names of cytokines on the Cytokine Antibody Arrays shown in Panel C-II. Shown in Panel A, B, and C-II were representative Western blots or Cytokine Arrays of three experiments with similar results.