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. Author manuscript; available in PMC: 2012 Apr 14.
Published in final edited form as: J Med Chem. 2011 Mar 7;54(7):2282–2292. doi: 10.1021/jm1014378

Scheme 3.

Scheme 3

a Synthesis of hydrophobic domain

aReagents and conditions: a) NaH, m-CPBA, THF, rt 32–72%; b) (i) CDI/toluene, reflux; then NH2OBn, reflux; (ii) NaOH/EtOH, reflux, 53%; c) benzyl bromide or 4-Flurobenzyl bromide, Cs2CO3, DMF, 80 °C, 58–67%; d) HBr (48% in H2O), reflux, 77–78%.