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. Author manuscript; available in PMC: 2012 Apr 14.
Published in final edited form as: J Med Chem. 2011 Mar 7;54(7):2282–2292. doi: 10.1021/jm1014378

Table 2.

Effects of linker domain on IN inhibition

graphic file with name nihms278867u2.jpg
Compd Linker IN IC50 (μM)a
3′P STb
4c CH2OCH2 >111 3.5 ± 0.6
28 (CH2)2OCH2 >111 1.6 ± 0.2
29 (CH2)3OCH2 >111 3.2 ± 0.5
30 (CH2)4OCH2 >111 4.5 ± 0.4
32 CH2 >111 22 ± 0.5
42 (CH2)2 >111 46 ± 6
43 (CH2)3 >111 0.44 ± 0.1
44 (CH2)4 >111 0.56 ± 0.04
a

Concentration inhibiting enzymatic function by 50%.

b

Mean value ± standard deviation from triplicate experiments.

c

Ref 30.