Table 2.

Male/female ratio of the pharmacokinetic parameters of some oral triptans

Triptan	Male/female ratio of pharmacokinetic parameters
	Bioavailability %	Cmax (ng/ml)	AUC0–∞ (ng h/ml)	Tmax (h)	Vd (L)	t½ (h)	CLp (ml/min)
Almotriptan 12.5 mg [22]	NS	NS	NS	NS	–	NS	NS
Frovatriptan 2.5 mg [21]	0.88	0.60	0.46a	0.66–0.77	1.66	1.07	1.64
Naratriptan 5 mg [19, 59]	0.85	0.79	0.66	–	–	–	1.25
Rizatriptan 5 mg [20, 60, 61]	–	0.96	0.78	0.77	1.31	0.92	1.27
Rizatriptan 10 mg [20, 60, 61]	–	0.89	0.74	1.00	1.38	0.92	1.22
Zolmitriptan 2.5 mg [18]	1.00b	0.87c	0.83d	1.54	1.04	0.90	1.13
Zolmitriptan 5 mg [18]	0.78	0.62	0.56	–	–	0.92	–

NS no statistically significant differences, – datum not available

^aAUC_0–12 = 0.63

^b95% CI = 0.84–1.26

^c95% CI = 0.60–1.05

^d95% CI = 0.61–1.09