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. Author manuscript; available in PMC: 2011 Apr 8.
Published in final edited form as: J Alzheimers Dis. 2010;20(Suppl 2):S609–S631. doi: 10.3233/JAD-2010-100564

Figure 3.

Figure 3

Electron microscopy in control N2a neurons, Aβ-incubated N2a cells, and N2a cells treated with MitoQ and SS31, and then incubated with Aβ (n=4). Image A shows (a) a control N2a cell compared to (b) a representative Aβ-incubated N2a cell. Mitochondria increased in the Aβ-incubated N2a cell, and they exhibited morphological changes, including swollen and damaged inner mitochondrial membrane and cristae. Image B shows high magnification of mitochondrial fragmentation of an Aβ-incubated N2a cell. Image C shows results from quantitative analysis of mitochondria: (a) in control N2a cell compared to N2a cells treated with MitoQ, SS31, and resveratrol, and then incubated with Aβ. Significantly increased mitochondria were found in Aβ-incubated N2a neurons (P<0.05) compared to the control N2a cells, and (b) in Aβ-incubated N2a cells compared to N2a cells treated with MitoQ, SS31, and resveratrol, and then incubated with Aβ. Significantly decreased mitochondria were found in the N2a cells treated with MitoQ and then incubated with Aβ (P<0.05), and in N2a neurons treated with SS31 and then incubated with Aβ (P<0.05), compared to Aβ-treated N2a cells.