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. Author manuscript; available in PMC: 2012 Mar 31.
Published in final edited form as: Neuroscience. 2011 Jan 9;178:45–55. doi: 10.1016/j.neuroscience.2011.01.011

Figure 1.

Figure 1

Representative phrenic neurograms from four rats that received episodic (top traces) or a single (bottom traces) intrathecal injection of agonists selective for (A) the 5-HT2a receptor (DOI, 100µM) or (B) the 5-HT2b receptor (BW723C86, 1mM). Note the increase in phrenic nerve burst amplitude (i.e. phrenic motor facilitation, pMF) up to 90 minutes following the last injection for each agonist, whereas a single injection had no effect. Open arrows indicate an injection of the agonist. In experiments that addressed the effects of episodic intrathecal injections, each injection was administered at 5 minute intervals (6µl/injection). Dashed line extrapolates baseline (i.e. pre-injection) nerve burst amplitude. 10 second bins illustrating several breaths for each rat are provided at the beginning of the traces.