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. Author manuscript; available in PMC: 2011 Apr 8.
Published in final edited form as: Exp Hematol. 2009 May 15;37(8):909–923. doi: 10.1016/j.exphem.2009.05.002

Figure 1.

Figure 1

The model of maintenance and multilineage differentiation of a multipotent hematopoietic cell line EML. In the presence of stem cell factor (SCF), EML cells undergo proliferative self-renewal and remain undifferentiated, whereas in the presence of cytokines and/or stroma EML cells differentiate into erythroid, myeloid, and lymphoid lineages. BFU-E = burst-forming unit erythroid; CFU-GM = colony-forming unit granulocyte macrophage; CFU-Meg = colony-forming unit megakaryocyte; Epo = erythropoietin; GM-CSF = granulocyte macrophage colony-stimulating factor; IL = interleukin; SCF = stem cell factor; TCR = T-cell receptor; Tpo = thrombopoietin.