Table 1.

T2D models	Description	Type 2 diabetic characteristics	Used in MI/IR studies?	References
ob/ob mouse	Leptin deficient	Obesity, dyslipidemia, insulin resistance, hyperinsulinemia, hyperglycemia, impaired glucose tolerance	Yes/Yes	16, 17, 18, 19
db/db mouse	Leptin resistant	Obesity, dyslipidemia, insulin resistance, hyperinsulinemia, hyperglycemia	Yes/Yes	17, 19, 20, 21
KK/Ay mouse	Genetically derived (Ay mutation)	Obesity, insulin resistance, hyperinsulinemia, islet cell hyperplasia, hyperglycemia, impaired glucose tolerance	No/No	16, 20, 22
Zucker (fa/fa) rat	Leptin resistant	Obesity, dyslipidemia, insulin resistance, hyperinsulinemia, hyperglycemia, impaired glucose tolerance, hypertension	Yes/Yes	20, 31, 32, 34
Goto Kakizaki rat	Spontaneous diabetes by selective breeding	Insulin resistance, hyperinsulinemia, hyperglycemia, impaired glucose tolerance	Yes/Yes	16, 20, 23, 32, 33
NZO mouse	Polygenic diabetes model by selective inbreeding	Obesity, insulin resistance, hyperinsulinemia, hyperglycemia, impaired glucose tolerance	No/No	20
NSY mouse	Spontaneous diabetes by selective inbreeding	Insulin resistance, hyperglycemia	No/No	16
OLETF rat	Spontaneous diabetes by selective inbreeding	Mild obesity, dyslipidemia, hyperinsulinemia, hyperglycemia, impaired glucose tolerance	No/Yes	16, 20, 30
Cohen diabetic rat	Diet-induced diabetes	Hyperinsulinemia, hyperglycemia, hypertension	No/No	20, 24, 25
Low dose ALX- or STZ-treated rodents	Chemical ablation of β cells	Dyslipidemia, hyperglycemia, hyperinsulinemia	Yes/Yes	20, 28, 29
C57BL/6J	High fat diet-induced	Obesity, dyslipidemia, insulin resistance, hyperglycemia, impaired glucose tolerance	Yes/Yes	20, 26, 27

NZO New Zealand obese, NYS Nagoya-Shibata-Yasuda, OLETF Otsuka Long-Evans Tokushima fatty, ALX alloxan, and STZ streptozotocin, IR ischemia/reperfusion