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. Author manuscript; available in PMC: 2012 Feb 15.
Published in final edited form as: J Immunol. 2011 Jan 17;186(4):2336–2343. doi: 10.4049/jimmunol.1003104

Figure 4. General genomic instability is unchanged in Exo1-XRCC4-, Msh2-XRCC4- and Mlh1-XRCC4- double deficient mice compared to XRCC4-deficient mice.

Figure 4

(A) Metaphases were prepared from B cells cultured with αCD40 plus IL4 for four days. Metaphases were hybridized with a fluorescently labeled telomere specific probe. Pictures show chromosomes from individual metaphases that are normal or contain DNA breaks or translocations. Cartoons depicting the status of the chromosomes shown in the metaphase pictures are displayed below the pictures. (B) Bar graphs represent percent of metaphases with chromosomal aberrations from 3 Exo1, 4 Mlh1-, 4 Msh2-, or 9 WT control mice. (C) As in (B), results are from 5 Exo1-XRCC4-, 3 WT and 4 XRCC4- mice. (D) As in (B), results are from 7 Mlh1-XRCC4 mice, 4 XRCC4- and 3 WT. (E) As in (B), results are from 9 Msh2-XRCC4- mice, 5 XRCC4- and 4 WT mice. Statistical significance was determined using a two-tailed T test.