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. Author manuscript; available in PMC: 2011 Apr 8.
Published in final edited form as: Methods Enzymol. 2009;467:547–581. doi: 10.1016/S0076-6879(09)67021-X

Table I.

Summary of core interactive constants in the auto-feedback MCN


Rate Constant Dose-Response Control Functions

Elimination
[1/hour]
Release
[concentration/hour]
ED50, or ID50
[concentration]
Slope
[dimension-
less]
Delay
[min]
Glucagon kGL = 22 h−1 rGL = 42,570pg/mL/h
rGL,basal = 2,128pg/mL/h
tGL = 85pg/mL nGL = 5 DGL = 7.2min

BG tBG = 50mg/dL
tBG,2 = 400mg/dL
nBG = 5
nBG,2 = 3

Insulin kINS = 14h−1 rINS = 80,000
rINS,basal = 270
tINS = 20

Pulse periodic function:
a square wave of height = 10 over a period of 36 sec recurring every 6 minutes