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. Author manuscript; available in PMC: 2011 Apr 8.
Published in final edited form as: Drug Metab Rev. 2010 Feb;42(1):182–194. doi: 10.3109/03602530903208652

Figure 2.

Figure 2

Analysis of glucuronidation activities against trans-4-OH-TAM and trans-endoxifen in HLM stratified by UGT2B7 genotypes. Glucuronidation assays were performed and 4-OH-TAM and endoxifen-glucuronides separated by ultrapressure liquid chromatography. (A) trans-4-OH-TAM and UGT2B7 codon 268 genotypes. (B) trans-endoxifen and UGT2B7 codon 268 genotypes. Comparative analysis was performed by using HLM from subjects with the homozygous wild-type UGT2B7268His genotype as the referent. *P < 0.001; **P < 0.002; error bars represent standard error.