TABLE 5.

Association of candidate genotypes with features of menopause: ORs with 95% CIs^a associated with genotype main effect as well as interaction with menopause status [with interaction P value]

Gene	Variant vs reference genotype comparison	African American		European American
		Depressive symptoms	Hot flashes	Depressive symptoms	Hot flashes
COMT	Met/Met vs Any Val	0.61 (0.31–1.17) [0.88]	1.29 (0.67–2.48) [0.76]	1.10 (0.67–1.79) [0.98]	0.82 (0.49–1.35) [0.09]
CYP19	264 Arg/Arg vs Any 264Cys	0.91 (0.58–1.44) [0.07]	0.68 (0.43–1.07) [0.62]	0.58 (0.27–1.25) [0.41]	0.86 (0.41–1.80) [0.75]
CYP1A2	Any *1F vs *1/*1	0.82 (0.46–1.46) [0.62]	1.04 (0.64–1.69) [0.006]	0.97 (0.55–1.73) [0.11]	0.96 (0.48–1.92) [0.54]
CYP1B1*3	Any *3 vs *1/*1	0.74 (0.48–1.15) [0.02]	0.62 (0.40–0.95) [0.93]	0.61 (0.35–1.06) [0.47]	0.94 (0.55–1.59) [0.39]
CYP1B1*4	Any *4 vs *1/*1	0.61 (0.30–1.21) [0.03]	0.66 (0.33–1.30) [0.54]	0.80 (0.51–1.26) [0.37]	1.20 (0.76–1.89) [0.44]
CYP3A4	Any *1B vs *1/*1	0.98 (0.58–1.66) [0.13]	1.10 (0.63–1.94) [0.50]	1.03 (0.48–2.19) [0.69]	0.87 (0.39–1.94) [0.12]
SULT1A1*2	Any *2 vs *1/*1	1.28 (0.82–2.0) [0.95]	0.77 (0.48–1.24) [0.31]	0.77 (0.50–1.17) [0.007]	0.75 (0.49–1.14) [0.34]
SULT1A1*3	Any *3 vs *1/*1	1.27 (0.81–1.97) [0.58]	0.95 (0.59–1.50) [0.88]	0.53 (0.41–0.68) –	2.08 (1.64–2.63) [<0.001]
SULT1E1 5′UTR	Any A vs G/G	0.68 (0.41–1.11) [0.89]	1.39 (0.86–2.23) [0.80]	0.97 (0.53–1.78) [0.12]	1.43 (0.77–2.63) [0.92]
SULT1E1 3′UTR	Any C vs T/T	1.33 (0.67–2.66) [0.08]	1.01 (0.49–2.10) [0.07]	0.91 (0.59–1.38) [0.87]	0.86 (0.57–1.31) [0.24]

OR, odds ratio.

^aORs were estimated from repeated-measures logistic regression analysis adjusted for the following variables: menopause status (late premenopause, early transition, late transition, postmenopausal).