Table 4.
Genetic Testing Uptake after Disclosure of Known BRCA1/2 Mutations
| Number tested/told (%)a,b | p-valuec | OR | CI | |
|---|---|---|---|---|
| First-degree relative | ||||
| Mother vs. father | 7/9 (78) vs. 9/12 (75) | 1.0 | 1.17 | 0.10–17.53 |
| Sister vs. brother | 122/155 (79) vs. 71/134 (53) | <0.01 | 3.28 | 1.91–5.67 |
| Daughter vs. son | 36/63 (57) vs. 15/47 (53) | 0.01 | 2.84 | 1.21–6.80 |
| Female vs. male | 165/227 (73) vs. 95/193 (49) | <0.01 | 2.75 | 1.79–4.21 |
| Second-degree relative | ||||
| Maternal aunt vs. maternal uncle | 17/27 (63) vs. 20/31 (65) | 1.0 | 0.94 | 0.28–3.14 |
| Paternal aunt vs. paternal uncle | 0/6 (0) vs. 0/3 (0) | — | — | — |
| Maternal lineage vs. paternal lineage | 37/58 (63) vs. 0/9 (0) | <0.01 | — | — |
| Niece vs. nephew | 30/36 (83) vs. 7/29 (24) | <0.01 | 15.71 | 4.05–64.36 |
| Female vs. male | 47/69 (68) vs. 27/63 (43) | <0.01 | 2.85 | 1.32–6.18 |
| FDR vs. SDR | 260/420 (61) vs. 74/132 (56) | 0.26 | 1.27 | 0.84–1.93 |
| Older vs. younger generationd | 246/377 (65) vs. 88/175 (50) | <0.01 | 1.86 | 1.27–2.72 |
| Female FDR and SDR vs. male FDR and SDR | 212/296 (72) vs. 122/256 (48) | <0.01 | 2.77 | 1.92–4.01 |
a
Denominator represents nonmissing data only and represents the number of people who were informed of genetic risk and who had genetic testing, based on knowledge of survey participant. Several participants answered unknown, so the denominator docs not match the number given for number told in Table 2 or 3.
b
Percent of people who received testing for BRCA1/2 status after a family member was diagnosed with the mutation (number tested/total number).
c
Two-sided Fisher’s exact test (FET).
d
Older generation (mother/father/aunt/uncle/sister/brother); younger generation (daughter/son/niece/nephew).