Table 1.
Secretory/Expression Products of Endothelial Cells*
| Extracellular matrix factors | Proteases |
|---|---|
| fibronectin | Thrombin |
| laminin | MMPs |
| collagen I, II, III, IV, VIII, XVIII | tPA |
| proteoglycans | Growth factors |
| Anti- and pro- coagulation factors | PDGF |
| PGI2 | EDGF |
| thrombomodulin | FGF |
| AT III | IGF |
| heparin sulfate | TGF-β |
| vWF | GM-CSF |
| TXA2 | G-CSF |
| thromboplastin | Vasorelaxation factors |
| Factor V | NO |
| PAF | PGI2/E2 |
| PAI-1, PAI-2 | EDHF |
| Inflammatory Chemokines and Cytokines | Vasoconstriction factors |
| IL-1, IL-6, IL-8 | TXA2/F2a |
| LTB4, C4, D4, E4 | EDCF |
| MCP-1, MCP-2 | leukotrienes |
| MHC II | free radicals |
| CAM | endothelin |
*See text for references
Abbreviations used: prostacyclin (PGI2), anti-thrombin III (AT III), von Willebrand factor (vWF), thromboxane A2 (TXA2), platelet-activating factor (PAF), plasminogen activator inhibitor-1 (PAI-1), plasminogen activator inhibitor-2 (PAI-2), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), leukotriene B4 (LTB4), leukotriene C4 (LTC4), leukotriene D4 (LTD4), leukotriene E4 (LTE4), monocyte chemoattractant protein-1 (MCP-1), monocyte chemoattractant protein-2 (MCP-2), major histocompatibility complex class II (MHC II), cell adhesion molecules (CAM), matrix metalloproteinases (MMPs), tissue plasminogen activator (tPA), platelet-derived growth factor (PDGF), endothelium derived growth factor (EDGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), transforming growth factor beta (TGF-β), granulocyte macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), nitric oxide (NO), prostacyclin/prostaglandin E2 (PGI2/E2), endothelium derived hyperpolarizing factor (EDHF), thromboxane A2/prostaglandin F2a (TXA2/F2a), endothelium derived contracting factor (EDCF)