Table 1.
Clinical characteristics at onset in type 1 diabetes subjects according to PTPN22 C1858T genotypes
| The HSG cohort | C1858T genotype | ||
|---|---|---|---|
| CC | CT | TT | |
| Sex (male/female) | 90/96 | 33/32 | 3/3 |
| Age (yrs) | 9.3 ± 0.3 | 8.8 ± 0.5 | 6.7 ± 1.1 |
| Presences of DKA (+/-) (%) | 22/78 | 13/87 | 17/83 |
| BMI (kg/m2) | 17.8 ± 0.2 | 18.0 ± 0.4 | 16.3 ± 0.6 |
| HLA risk genes: (Caucasian/Japanese = 253/4) | |||
| Low (%) | 52/0.8 * | 46 | 17 |
| Moderate (%) | 11/0.4 * | 14 | 17 |
| High (%) | 37/0.4 * | 40 | 67 |
Data are mean values ± SEM. HLA DRB1 high risk genotypes: DR 03/04 and DR 04/04; HLA DRB1 moderate risk genotypes: DR 03/03 and DR04/08; all other HLA DRB1 genotypes were considered low risk. The HLA DRB1 genotypes for the 4 Japanese patients were: DR 01/09, DR 04/08, DR 09/09 and DR 04/09. These were classified as HLA risk: low, low, moderate and high, respectively* [20].