Table 4.
Associations between APE1/Ref-1 rs1760944 and risk of different histological types of gliomas
| rs1760944 | Controls (824) | Glioblastoma (241) | Astrocytomas (284) | Other gliomas (241) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) | No. (%) | Pa | OR (95% CI) b | Pc | No. (%) | Pa | OR (95% CI) b | Pc | No. (%) | Pa | OR (95% CI) b | Pc | |
| Alleles | |||||||||||||
| T | 898 (55.0) | 286 (60.6) | 0.032 | 1.00 (reference) | 0.032 | 309 (55.6) | 0.821 | 1.00 (reference) | 0.821 | 263 (55.7) | 0.783 | 1.00 (reference) | 0.783 |
| G | 734 (45.0) | 186 (39.4) | 0.80 (0.65-0.98) | 247 (44.4) | 0.98 (0.81-1.19) | 209 (44.3) | 0.97 (0.79-1.19) | ||||||
| Genotypes | |||||||||||||
| TT | 237 (29.0) | 81 (34.3) | 0.041 | 1.00 (reference) | 86 (30.9) | 0.634 | 1.00 (reference) | 66 (28.0) | 0.592 | 1.00 (reference) | |||
| TG | 424 (52.0) | 124 (52.6) | 0.84 (0.60-1.17) | 0.298 | 137 (49.3) | 0.87(0.64-1.19) | 0.390 | 131(55.5) | 1.11(0.79-1.56) | 0.539 | |||
| GG | 155 (19.0) | 31 (13.1) | 0.54 (0.34-0.87) | 0.012 | 55 (19.8) | 0.99(0.66-1.47) | 0.950 | 39 (16.5) | 0.91(0.58-1.43) | 0.686 | |||
| Pd for trend = 0.014 | Pd for trend = 0.832 | Pd for trend = 0.813 | |||||||||||
aAllele and genotype frequencies in cases and controls were compared using χ2 test.
bAllele-specific ORs were not adjusted; genotype-specific ORs were adjusted for age and gender.
cP value from unconditional logistic regression analyses.
dTrend tests were calculated using the genotype as an ordinal variable in the regression model.