Figure 3. Relationship of Na⁺ channel-associated parameters with oxaliplatin dose level in motor axons.

A) Relationship of Na⁺ channel-associated parameters with single oxaliplatin dose level in motor axons. Patients were divided into three single dose levels with means of 66, 85 and 105 mg/m². Change in refractoriness was significantly correlated with increasing single dose (correlation coefficient = .80; P≤.001). B) Correlation of cumulative oxaliplatin dose with the change in strength-duration time constant post-oxaliplatin in motor axons, illustrating the association of higher cumulative doses with an increase in strength-duration time constant (Correlation coefficient = .75; P≤.001). C) Relationship of changes in refractoriness compared to changes in SDTC in motor axons. Change in refractoriness post-oxaliplatin was significantly associated with change in SDTC post-oxaliplatin (correlation coefficient = −.65; P<.05).