Table 2. A comparative analysis of subunit structure of Mtb BfrB with representative ferritins from archaea, eubacteria and eukarya using the DaliLite -pairwise option vs 3.1.

Organism (ferritin annotation)	PDB-Chain	Z score	RMSD (Å)	Naligned	Total N	Identity (%)	Solvation Energy (kcal/mol)	Reference
Eubacteria ferritins
M. tuberculosis	BfrB_A	-	-	-	181		−3956.8	This study
C. jejuni	1krq_A	22.9	1.1	156	164	24	−3651.4	Unpublished
H. pylori	3bve_A	22.4	1.2	157	173	19	−3343.4	[18]
E. coli	1eum_A	22.4	1.3	154	161	19	−4140.6	[15]
Archaebacteria ferritins
P. furiosus	2jd6_O	22.4	1.8	156	167	27	−3855.4	[16]
A. fulgidus	1s3q_J	22.1	1.6	157	164	27	−4576.6	[17]
T. maritima	1vlg_A	22.0	1.7	157	164	24	−4473.6	Unpublished
Eukaryotic ferritins
Human H -chain	2cei_A	20.8	1.2	151	172	25	−3798.2	[7]
Insect H-chain	1z6o_M	19.1	1.5	151	191	27	−3528.0	[14]
Insect L-chain	1z6o_A	17.7	1.7	150	212	17	−3642.5	[14]
Horse spleen	1ies_A	20.6	1.2	152	174	18	−2991.4	[11]
Mouse L-chain	1h96_A	20.5	1.2	151	166	19	−3062.5	[74]
Bullfrog L ferritin	1rcc_A	20.0	1.8	155	171	23	−2435.0	[9]
Human Mitochondria	1r03_A	20.7	1.2	151	170	25	−4213.3	[75]
Bullfrog M ferritin	1mfr_A	20.3	1.6	154	171	25	−3999.9	[8]
Soybean	3a68_A	20.2	1.2	153	194	28	−4673.3	[13]
Mycobacterial heme-containing bacterioferritins (Bfrs)
M. tuberculosis (BfrA)	2wtl_A	17.0	2.3	148	161	20	−5109.5	[38]
M. smegmatis (Bfr)	3bkn_A	17.2	2.2	148	161	20	−4388.7	[76]
Mycobacterial DNA binding proteins from starved cells (Dps)
M. smegmatis (Dps1)	1vei_A	13.0	2.4	131	175	11	−4189.0	[58]
M. smegmatis (Dps2)	2z90_A	12.7	2.4	130	161	12	−3964.8	[77]