Skip to main content
. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Drug Discov Today. 2011 Feb 17;16(7-8):325–331. doi: 10.1016/j.drudis.2011.02.008

Table 3.

mTORC1/mTORC2 dual inhibitors in vitro kinase IC50 (nM)

PP242 [31] PP30 [31] WAY600 [34] WYE687 [34] WYE354 [34] WYE132 [35] AZD8055 [37] Ku0063794 [42]
mTOR 8 80 9 7 5 0.19 ± 0.07 0.8/0.13 3/16
PI3Kα 1960 3000 1960 810 1890 1179 3590 8900
PI3Kβ 2200 5800 n.d. n.d. n.d. >10000 18900 >30000
PI3Kγ 1270 990 8450 3110 7370 >10000 >14790 >30000
PI3Kδ 102 680 n.d. n.d. n.d. 2380 3200 >5300
DNA-PK 408 339 n.d. n.d. n.d. n.d. 1370 >10000
Chemical structure graphic file with name nihms277443t9.jpg graphic file with name nihms277443t10.jpg graphic file with name nihms277443t11.jpg graphic file with name nihms277443t12.jpg graphic file with name nihms277443t13.jpg graphic file with name nihms277443t14.jpg graphic file with name nihms277443t15.jpg graphic file with name nihms277443t16.jpg
Inventor Intellikine Intellikine Wyeth Wyeth Wyeth Wyeth AstraZeneca AstraZeneca

n.d., not determined.