Table 2.
Potential questions | Examples of study measures that can be performed to address the questions |
---|---|
Are existing pattern-based AF classes valid and reliable? |
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Are existing pattern-based AF classes or AF progression associated with differences in health outcomes that are independent of comorbid conditions? |
|
Do biological subtypes of disease manifest as different pattern-based classes of AF? |
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Can individuals at risk of new-onset, recurrent, or progressive AF be identified? |
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Can new-onset, recurrent, or progressive AF be prevented? |
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How does AF class change over time in each individual? |
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Is there utility in preventing the progression of AF? |
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What accounts for variability in AF patterns and progression? |
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Does classification of patient well-being inform prognosis and clinical management? |
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Can novel classification schemes explain variability in clinical outcomes better than existing pattern-based classification? |
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Abbreviation: AF, atrial fibrillation