Table 1.

Genes and loci implicated in familial atrial fibrillation

Genes	Chr	Gene name	Effect	Inheritance	Reference
	11p15.5	KCNQ1/KvLQT1	Increases IKs, Expected to shorten APD	AD	[10, 14]
	21q22.1	KCNE2/MiRP1	Increases IKs	AD	[11]
	17q23.1-24.2	KCNJ2	Increases IK1; Expected to shorten APD	AD	[12]
	12p13	KCNA5	Loss of IKur; prolongs APD	AD	[13]
	3p21	SCN5A	Hyperpolarizing shift of resting membrane potential; Expected to prolong APD	AD	[15–17]
	1p36-p35	NPPA	Results in mutant atrial natriuretic peptide; associated with shortened APD	AD	[26]
Genetic Loci	Chr	Gene	Comments	Inheritance	Reference
	5p13	Unknown	Associated with sudden death	AR	[24]
	6q14-q16	Unknown	Overlaps with locus for DCM	AD	[23]
	10q22-q24	Unknown	Overlaps with locus for DCM	AD	[22]
	10p11-q21	Unknown		AD	[25]

Abbreviations: Chr, Chromosome; AD, autosomal dominant; AR, autosomal recessive; DCM, dilated cardiomyopathy.