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Mean plasma methylcitrate levels. Normal plasma (n = 9) is from Pcca+/+ and Pcca+/– mice at day of life 1. Because of neonatal lethality, Pcca+/+ plasma (n = 4) was collected at day of life 1 from untreated Pcca–/– mice (n = 5). Pcca–/– AAV8-PCCA plasma (n = 7) was collected from Pcca–/– mice that received an injection of AAV8 carrying the human PCCA cDNA between day of life 22 and 28. Error bars represent ± 1 SD. *p = 0.01 (t test).
