Table 1.

IC₅₀ Values of 5-FU and 5-FC for Melanoma Cells Transduced with Ad5Luc1 or Ad5CMVFCU-1 or Mock-Infected

	IC50 (μM)
	SK-MEL-28	Colo829	Mel624	Mel888	A375M	C8161
5-FU	10.1	10	3.3	7.8	5.7	8.6
5-FC	>10,000	>10,000	>10,000	>10,000	>10,000	>10,000
Ad5Luc1/5-FU	9.7	14.5
Ad5Luc1/5-FC	>10,000	>10,000
Ad5CMVFCU/5-FU	3.9	1.6
Ad5CMVFCU/5-FC	45	2.5

Titers of Ad vectors were 2 TCID₅₀ per cell, resulting in transduction of <18% or <6% of cells for SK-MEL-28 or Colo829, respectively.