Skip to main content
. Author manuscript; available in PMC: 2012 Apr 15.
Published in final edited form as: Clin Cancer Res. 2010 Dec 22;17(8):2314–2327. doi: 10.1158/1078-0432.CCR-10-1903

Figure 1. An IGF gene signature is reversed by treatment of cancer xenografts and IGF-IR overexpressing NIH3T3 fibroblasts with anti-IGF-IR inhibitors.

Figure 1

Genes in the IGF-I gene signature derived from MCF-7 cells stimulated with IGF-I (31) were examined in A. a gene expression profile of neuroblastoma (SK-N-AS) xenografts treated with vehicle or an anti-IGF-R antibody and in B. IGF-IR transfected NIH3T3 fibroblasts treated with an IGF-IR small molecule inhibitor and in C. colon cancer xenografts treated with the small molecule inhibitor BMS-754807. For A-C, relative gene expression is represented using a yellow–blue color scale; patterns for genes that are upregulated (yellow) in the IGF gene signature are separate from the patterns for genes that are downregulated (blue)..

HHS Vulnerability Disclosure