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. Author manuscript; available in PMC: 2012 Apr 15.
Published in final edited form as: Clin Cancer Res. 2010 Dec 22;17(8):2314–2327. doi: 10.1158/1078-0432.CCR-10-1903

Figure 2. IGF gene signature is present in triple-negative/basal-like breast cancer cell lines.

Figure 2

Breast cancer cell line profiles were classified using the Hoadley dataset, where intrinsic subtypes were previously defined. The correlation was computed between a given cell line gene expression profile and the mean centroid of each subtype; cell lines were then assigned to a subtype with the highest correlation. A. The heatmap represents the IGF gene signature in the cell lines according to subtype. ER, PR, and HER-2 mRNA levels are shown. In addition, the breast cancer subtype is indicated as defined in the original gene expression study by Neve et al. B. The graph represents the t-score for each cell line based on the similarity to the IGF signature.

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