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. Author manuscript; available in PMC: 2011 Apr 10.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Jun 11;29(9):1376–1382. doi: 10.1161/ATVBAHA.109.191585

Figure 5.

Figure 5

Figure 5

Figure 5

PTX inhibits lysoPC-induced phosphorylation of PKD2 and p38 in monocytic cells and knockdown of G2A expression by G2A siRNA blocks lysoPC-induced PKD2 phosphorylation. A, Effect of PTX on lysoPC-induced PKD2 activation (Western analysis). THP-1 cells were pretreated with PTX at the indicated concentrations for 16 h and then were treated with lysoPC (15 μmol/L) for 2 min. PKD2 activation was analyzed by Western analysis. B, PKD2 phosphorylation was quantified by densitometry. Data are means ± SE from 4 independent experiments. C, PTX blocks lysoPC-induced p38 phosphorylation (Western analysis). D, Knockdown of G2A expression by G2A siRNA reduces lysoPC-induced phosphorylation of PKD2.