Table 3.

B. anthracis chromosomal genes downregulated in the 34F₂ΔluxS strain as determined by microarray analysis, sorted by locus

Locusc	Gene nameb	30 mina	60 min	90 min	120 min
BA0238	hypothetical protein	−3.41	−29.65	−5.78	−15.78
BA0239	hypothetical protein	−3.86	−22.16	−5.86	−19.29
BA0240	4-hydroxyphenylpyruvate dioxygenase (hppD)	NaN	−11.63	−9.51	−6.41
BA0509	formate acetyltransferase (pfl)	−33.13	−125.37	−56.89	−35.51
BA0510	pyruvate formate-lyase-activating enzyme (pflA)	−1.26	−23.26	−36.00	−21.71
BA0668	ribose ABC transporter, permease protein (rbsC)	−1.42	−14.42	−12.91	−7.94
BA0669	ribose ABC transporter, ribose-binding protein (rbsB)	−1.58	−15.89	−11.88	−6.96
BA0887	S-layer protein EA1 (eag)	−7.26	−25.63	−46.85	−3.97
BA1086	sugar-binding transcriptional regulator, LacI family	−3.14	−19.29	−11.08	−4.20
BA2125	respiratory nitrate reductase, alpha subunit (narG)	−6.68	−4.20	−52.71	−42.22
BA2126	respiratory nitrate reductase, beta subunit (narH)	−1.13	−3.18	−29.24	−17.39
BA2128	respiratory nitrate reductase, gamma subunit (narI)	−1.25	−3.12	−38.59	−18.13
BA2133	molybdenum cofactor biosynthesis protein A (narA-1)	−1.84	−6.36	−45.25	−14.83
BA2134	molybdopterin biosynthesis protein MoeB, putative	−1.07	−5.06	−103.97	−13.55
BA2135	molybdopterin biosynthesis protein MoeA (moeA-1)	−1.12	−2.19	−35.26	−13.64
BA2136	molybdopterin converting factor, subunit 2 (moaE-1)	−1.13	−2.95	−48.84	−20.53
BA2137	molybdopterin converting factor, subunit 1 (moaD-1)	−1.36	−1.91	−22.78	−29.86
BA2138	nitrate transporter (narK)	−1.24	−1.92	−37.53	−21.11
BA2146	nitrite reductase [NAD(P)H], large subunit (nirB)	−1.33	−76.11	−60.97	−210.84
BA2267	alcohol dehydrogenase, zinc-containing	−3.61	−12.91	−6.45	−9.19
BA2295	acetate CoA-transferase, subunit A (atoD)	−1.01	NaN	−8.11	−22.16
BA2350	carboxyvinyl-carboxyphosphonate phosphorylmutase (yqiQ)	−1.52	−5.24	−12.13	−19.16
BA2547	acyl-CoA dehydrogenase	−2.01	−13.36	−19.70	−10.48
BA2548	acetyl-CoA carboxylase, biotin carboxylase, putative	−1.66	−7.06	−17.27	−9.99
BA2552	carboxyl transferase domain protein	−1.24	−16.45	−11.39	−10.27
BA3479	transcriptional regulator, ArsR family	−36.00	−44.94	−37.27	−136.24
BA3481	hypothetical protein	−38.85	−315.17	−137.19	−69.55
BA3482	conserved hypothetical protein	−32.67	−36.00	−64.45	−140.07
BA3483	conserved hypothetical protein	−30.48	−67.18	−53.82	−219.79
BA3663	anaerobic ribonucleoside-triphosphate reductase	NaN	−14.03	−4.66	−9.92
BA5047	autoinducer-2 production protein LuxS (luxS)	−14.72	−28.84	−29.86	−494.56
BA5696	superoxide dismutase, Mn (sodA-2)	−1.77	−7.62	−14.62	−7.11

^aNumbers represent fold change over the 120 min time course of the experiments;

^bFunctional annotations were obtained from the B. anthracis complete genome sequence (www.jcvi.org);

^cLocus based on Ames strain of B. anthracis;

^dNaN indicates a miss data point.