Table 4.
Locusc | Gene nameb | 30 mina | 60 min | 90 min | 120 min |
BXA0142 | calmodulin-sensitive adenylate cyclase (cya) | 1.03 | −2.00 | −3.46 | −4.69 |
BXA0146 | transcriptional activator AtxA (atxA) | −1.34 | −1.16 | −1.25 | −1.83 |
BXA0164 | protective antigen (pagA) | −1.02 | −1.53 | −7.21 | −26.17 |
BXA0165 | hypothetical protein | 1.21 | −1.74 | −7.52 | −20.97 |
BXA0166 | transcriptional repressor PagR (pagR) | −1.13 | −2.13 | −6.11 | −13.36 |
BXA0167 | hypothetical protein | 1.36 | −1.39 | −5.70 | −10.27 |
BXA0168 | hypothetical protein | −1.20 | −1.13 | −2.46 | −2.62 |
BXA0169 | hypothetical protein | −1.23 | −1.20 | −2.10 | −2.89 |
BXA0170 | hypothetical protein | −1.24 | 1.16 | −1.71 | −4.23 |
BXA0171 | ribonuclease domain protein | −1.59 | −1.49 | −2.99 | −7.62 |
BXA0172 | lethal factor (lef) | −1.02 | 1.05 | −2.71 | −4.92 |
Numbers represent fold change over the 120 min time course of the experiments; Bolded genes indicate genes involved in B. anthracis toxin production or its regulation;
Functional annotations were obtained from the B. anthracis complete genome sequence (www.jcvi.org);
Locus based on Ames strain of B. anthracis.