Table 4.

Select genes downregulated on pXO1 in B. anthracis 34F₂ΔluxS as determined by microarray analysis, sorted by locus

Locusc	Gene nameb	30 mina	60 min	90 min	120 min
BXA0142	calmodulin-sensitive adenylate cyclase (cya)	1.03	−2.00	−3.46	−4.69
BXA0146	transcriptional activator AtxA (atxA)	−1.34	−1.16	−1.25	−1.83
BXA0164	protective antigen (pagA)	−1.02	−1.53	−7.21	−26.17
BXA0165	hypothetical protein	1.21	−1.74	−7.52	−20.97
BXA0166	transcriptional repressor PagR (pagR)	−1.13	−2.13	−6.11	−13.36
BXA0167	hypothetical protein	1.36	−1.39	−5.70	−10.27
BXA0168	hypothetical protein	−1.20	−1.13	−2.46	−2.62
BXA0169	hypothetical protein	−1.23	−1.20	−2.10	−2.89
BXA0170	hypothetical protein	−1.24	1.16	−1.71	−4.23
BXA0171	ribonuclease domain protein	−1.59	−1.49	−2.99	−7.62
BXA0172	lethal factor (lef)	−1.02	1.05	−2.71	−4.92

^aNumbers represent fold change over the 120 min time course of the experiments; Bolded genes indicate genes involved in B. anthracis toxin production or its regulation;

^bFunctional annotations were obtained from the B. anthracis complete genome sequence (www.jcvi.org);

^cLocus based on Ames strain of B. anthracis.