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. Author manuscript; available in PMC: 2011 Apr 11.
Published in final edited form as: Cell. 2008 Aug 22;134(4):657–667. doi: 10.1016/j.cell.2008.06.049

Figure 1. Senescent cells are present in fibrotic livers.

Figure 1

A. CCl4 (Fibrotic) but not vehicle (control) treated livers exhibit fibrotic scars (evaluated by H&E and Sirius Red staining). Multiple cells in the areas around the scar stain positively for senescence markers (SA-β-gal and p16 staining). B. The cells around the scar also co-express senescence markers p21, p53 and Hmga1, and are distinct from proliferating Ki67 positive cells. Numbers in the lower left corner indicate number of double positive cells (yellow) out of p21 positive cells (green). Scale bars are 50 μm.