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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Hepatology. 2011 Feb 11;53(3):974–982. doi: 10.1002/hep.24132

Figure 2. Dose-response for APAP toxicity in HepaRG cells.

Figure 2

Confluent cells were treated with various concentrations of APAP and GSH, APAP-protein adducts, JC-1 fluorescence, and LDH release were measured before and 24h after APAP treatment (0–20 mM) as described in the methods section. (A) Cellular glutathione content (B) APAP-protein adducts (C) Ratio of red to green fluorescence of the JC-1 assay (D) Percentage of total LDH activity found in culture medium. Data are expressed as mean ± SE of 3–4 independent cell preparations. *P<0.05 (compared to controls)