Table 3.
Comparison of the Ability of AIMs to Distinguish Different Continental Populationsa
| number of AIMs (4 Pop In)b | number of AIMs (4 Pop In) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 128 | 96 | 64 | 48 | 24 | 128 | 96 | 64 | 48 | 24 | |
| Subject Group | >10% non-EURA Ancestryc | >15% non-EURA Ancestry | ||||||||
| EURA (188) | 0.04 | 0.05 | 0.03 | 0.09 | 0.09 | 0.01 | 0.01 | 0.02 | 0.02 | 0.05 |
| AFR (98) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| AMI (105) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| EAS (188) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| SAS (64) | 0.98 | 0.95 | 0.94 | 0.83 | 0.64 | 0.97 | 0.97 | 0.83 | 0.73 | 0.47 |
| AFA (88) | 0.99 | 0.99 | 0.99 | 0.99 | 0.99 | 0.99 | 0.99 | 0.99 | 0.99 | 0.99 |
| PRA (28) | 1.00 | 1.00 | 0.96 | 0.96 | 0.89 | 1.00 | 0.96 | 0.93 | 0.86 | 0.79 |
| MAM/MXN (66) | 1.00 | 1.00 | 1.00 | 1.00 | 0.97 | 1.00 | 1.00 | 0.98 | 0.98 | 0.97 |
| >10% non-AFR Ancestry | >15 % non-AFR Ancestry | |||||||||
| EURA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| AFR | 0.04 | 0.04 | 0.02 | 0.09 | 0.07 | 0.03 | 0.03 | 0.01 | 0.02 | 0.03 |
| AMI | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| EAS | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| SAS | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| AFA | 0.88 | 0.88 | 0.88 | 0.84 | 0.80 | 0.77 | 0.78 | 0.77 | 0.75 | 0.73 |
| PRA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| MAM/MXN | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| >10% non-AMI Ancestry | >15% non-AMI Ancestry | |||||||||
| EURA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| AFR | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| AMI | 0.17 | 0.23 | 0.22 | 0.26 | 0.31 | 0.10 | 0.08 | 0.12 | 0.13 | 0.19 |
| EAS | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| SAS | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| AFA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| PRA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| MAM/MXN | 0.95 | 0.97 | 0.95 | 0.97 | 0.95 | 0.95 | 0.95 | 0.92 | 0.91 | 0.83 |
| >10% non-EAS Ancestry | >15% non-EAS Ancestry | |||||||||
| EURA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| AFR | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| AMI | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 |
| EAS | 0.12 | 0.14 | 0.17 | 0.26 | 0.61 | 0.06 | 0.06 | 0.08 | 0.13 | 0.42 |
| SAS | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| AFA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| PRA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| MAM/MXN | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.98 |
a
The ability to exclude subjects based on different numbers of AIMs is shown using both 10% and 15% non-Ancestry group membership.
b
The top of each column indicates the number of AIMs in each set. The AIMs were selected based on informativeness in four population groups (see Methods). Analyses were performed using K = 4.
c
For each set the criteria for exclusion is shown. The fraction of subjects that would be excluded for each criterion is indicated for each subject group.