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. Author manuscript; available in PMC: 2011 Apr 11.
Published in final edited form as: Chemistry. 2009 Sep 7;15(35):8670–8676. doi: 10.1002/chem.200900821

Figure 4.

Figure 4

Possible mechanisms for metal-promoted hydrolysis of a peptide bond showing (A) template effect, (B) Lewis acid activation of the electrophilic center, and (C) Lewis acid activation of the nucleophile.