Skip to main content
. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Eur J Immunol. 2011 Feb 11;41(3):863–872. doi: 10.1002/eji.201040649

Figure 1. IFNα in vivo elicits long-term production of ASCs in NZB/W but not in BALB/c mice.

Figure 1

(A) Frequency of spleen IgG ASCs was determined by ELISPOT. Results are the means ± SD of three mice in each group from two independent experiments. Neg, young untreated NZB/W mice; pos, old proteinuric untreated NZB/W mice; UNT, untreated; CT, control adenovirus (CT Adv)-treated; IFNα, interferon alpha (IFNα Adv)-treated. (B) Spleen and lymph node cells were stained with fluorescent anti-B220 and anti-CD138 Abs, and the frequency of ASCs analyzed by FACS at day 42 post-treatment. Data shown are representative of eight experiments (C) Immunofluorescence staining of plasma cells in spleen sections from IFNα-treated NZB/W mice for CD4 (green), CD138 (blue), and B220 (red). T, T cell zone; J, junction of the T cell zone; R, red pulp; G, germinal center. Data shown are representative of four experiments.