Table 3.

Age-adjusted ORs for disease-specific admission by HbS genotype

Case category	HbAA	HbAS	P	SCA	P
Uncomplicated malaria	1	0.24 (0.17-0.36)	< .001	0.43 (0.09-2.10)	.30
Severe malaria	1	0.12 (0.08-0.18)	< .001	0.80 (0.25-2.51)	.70
Nonmalaria illnesses	1	0.78 (0.60-1.01)	.066	4.17 (1.95-8.92)	< .001
Bacteremia	1	0.60 (0.48-0.76)	< .001	8.73 (4.51-16.89)	< .001

Values are ORs (95% CI) compared with the reference group (HbAA) adjusted for age group (0-23 months, 24-59 months) by logistic regression. Case categories are as defined in “Study participants.” In a subanalysis restricted to bacteremia caused by the rapidly progressive condition Streptococcus pneumoniae, the OR for SCA in cases versus controls was 15.3 (95% CI, 7.3-35.1; P < .001).