Table 4.

Unadjusted within-pair differences in plasma inflammatory biomarker levels based on CFR discordance status.

	Geometric Means of Inflammatory Markers (SE) (122 Twin Pairs)				Geometric Means of Inflammatory Markers (SE) (50 twin pairs)
	Twin with Lower CFR	Twin with Higher CFR	Within-Pair Differenc e (%)	P	Twin with CFR <2.5	Twin with CFR ≥2.5	Within-Pair Differenc e (%)	P
CRP (mg/L)	1.40 (1.11)	1.10 (1.12)	21.0	0.04	1.67 (1.18)	1.01 (1.18)	65.4	0.006
IL-6 (pg/dL)	2.04 (1.07)	1.65 (1.07)	18.7	0.02	2.65 (1.11)	1.72 (1.11)	54.2	0.002
WBC (1000/μL)	6.35 (1.02)	5.87 (1.02)	7.5	0.005	6.44 (1.04)	5.89 (1.04)	9.3	0.04
ICAM-1 (ng/mL)	323 (1.02)	302 (1.02)	6.6	0.02	336 (1.04)	303 (1.04)	11.0	0.02
VCAM-1 (ng/mL)	614 (1.03)	573 (1.03)	6.7	0.04	603 (1.05)	580 (1.05)	4.0	0.46

CFR: coronary flow reserve; CI: confidence interval; SE: standard error; CRP: C-reactive protein; IL-6: interleukin-6; WBC: white blood cell count; VCAM-1: vascular cell adhesion molecule-1; ICAM-1: intercellular adhesion molecule-1.

CFR is defined as the ratio of myocardial blood flow during adenosine to flow at baseline. All values in table are derived from mixed models with random intercept for pair.