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. 2010 Feb 4;19(9):1375–1383. doi: 10.1089/scd.2009.0258

FIG. 3.

FIG. 3.

Behavioral and biochemical analysis of parkinsonian rats. (A) Apomorphine-induced rotation in the group of rats transplanted with SHED-derived spheres (n = 12) was ameliorated to a greater extent compared to the negative control group (n = 12), as observed starting 2 weeks after transplantation and then throughout the observation period. This recovery was similar to the intact SHED graft group (n = 12) 2–4 weeks after transplantation, but a better recovery effect was evident in the SHED-derived spheres group. The rats in the control group showed no significant improvement. (B) DA content in the striatum, which reflects the level of active neurotransmitter and its usage efficiency, was measured by high-performance liquid chromatography (HPLC). To avoid variation among individual rats, the result was presented as the ratio of the DA level of the lesion side versus the contralateral (normal) side, which may reflect the actual degree to which synthesis of the neurotransmitter recovered. DA content in the group transplanted with SHED-derived spheres (n = 4) was significantly elevated 6 weeks after transplantation compared to the control group (n = 4) and intact SHED group. *P < 0.05; **P < 0.01.