Table 1.
Characteristics of AML patients expressing Id
| No. | No. of Id1 positive (%) |
No. of Id2 positive (%) |
No. of Id3 positive (%) |
|
|---|---|---|---|---|
| Sex | ||||
| Male | 137 | 23 (17) | 21 (15) | 3 (2) |
| Female | 148 | 27 (18) | 34 (23) | 1 (1) |
| Age (year) | ||||
| < 35 | 76 | 19 (25) | 12 (16) | 2 (3) |
| 35–60 | 177 | 28 (16) | 36 (20) | 1 (1) |
| > 60 | 32 | 3 (9) | 7 (21) | 1 (3) |
| WBC count (× 109 per liter) | ||||
| ≤ 20 | 113 | 18 (16) | 29 (26) | 4 (4)* |
| > 20 | 157 | 32 (20) | 26 (17) | 0 (0) |
| FAB | ||||
| M0 | 6 | 1 (17) | — | — |
| M1 | 57 | 11 (19) | 15 (26) | — |
| M2 | 59 | 10 (17) | 9 (15) | — |
| M3 | 18 | 3 (17) | 2 (11) | — |
| M4 | 46 | 8 (17) | 9 (19) | 2 (3) |
| M5 | 64 | 7 (11) | 15 (23) | 1 (2) |
| M6 | 3 | 1 (33) | 1 (33) | — |
| Not determined | 32 | 9 (28) | 4 (12) | 1 (3) |
| Cytogenetic abnormalities | ||||
| t(11q23) | 3 | — | — | — |
| −5/7(q) | 18 | 11 (61)* | 9 (50)** | 3 (17)* |
| +8 | 16 | 3 (19) | 4 (25) | — |
| −9q | 3 | — | 1 (33) | — |
| Inv(16)/t(16:16) | 19 | 2(11) | 2 (11) | — |
| t(15;17) | 18 | 5 (28) | 4 (22) | — |
| t(6;9) | 4 | 1 (25) | — | — |
| t(8;21) | 22 | 2 (9) | 1 (4.5) | — |
| t(9;22) | 1 | 1 (100) | 1 (100) | — |
| Normal karyotype | 121 | 20 (17) | 17 (14) | — |
| Complex (> 3 chromosome aberrations) | 7 | 1 (14) | 3 (43) | — |
| Other abnormal karyotypes | 34 | 2 (6) | 9 (27) | — |
| Failure | 4 | 1(25) | 1 (25) | — |
| Not determined | 10 | 1 (10) | 1 (10) | 1 (10) |
| Molecular abnormalities | ||||
| FLT3-ITD | 78 | 23 (29)** | 7 (9)** | — |
| FLT3-TKD | 33 | 7 (21) | 7 (21) | — |
| NRAS | 26 | 4 (15) | 8 (30)* | — |
| KRAS | 9 | — | 4 (44) | — |
| CEBPA | 17 | — | 1 (6) | — |
| EVI1 | 23 | 8 (35)* | 7 (30) | 3 (13)*** |
Abbreviation: FAB, French–American–British subtypes. P-values calculated using χ2-test,
*
P = 0.05–0.01,
**
P = 0.01–0.001,
***
P < 0.001.