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. Author manuscript; available in PMC: 2011 Apr 11.
Published in final edited form as: Trends Cell Biol. 2008 Nov 20;19(1):16–23. doi: 10.1016/j.tcb.2008.10.003

Figure 3.

Figure 3

Functions of 14-3-3 in cytokinesis. (a) 14-3-3σ function is required for a mitotic translational switch. During mitosis, binding of 14-3-3σ to eIF4B and possibly to other factors involved in cap-dependent translation is required for the mitotic switch from cap-dependent to cap-independent translation. This translational switch is needed for the synthesis of key mitotic regulators required for proper mitotic exit and cytokinesis. mRNA shown as red line. Abbreviations: IRES, internal ribosome entry site. (b) 14-3-3 function in abscission. During mitosis, phosphorylation mediated by p38, GSK3 and PKCε generates 14-3-3 binding sites on PKCε. Binding of 14-3-3 activates PKCε and formation of the active PKCε–14-3-3 complex is needed to limit RhoA activity at the midbody, which in turn enables the actomyosin ring to dissociate during the final stages of abcission.