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. Author manuscript; available in PMC: 2011 Apr 11.
Published in final edited form as: Trends Cell Biol. 2008 Nov 20;19(1):16–23. doi: 10.1016/j.tcb.2008.10.003

Figure 4.

Figure 4

Functions of 14-3-3 in tumor-suppressor pathways. (a) The mammalian Hippo pathway transmits signals received at the cell surface, such as cell–cell contact, through the sequential activation of the Mst1/2–WW45 and Lats1/2–Mob kinase complexes. The Lats kinases phosphorylate YAP and TAZ on sites that mediate 14-3-3 binding, thus, inactivating the function of these transcriptional coactivators by means of their cytoplasmic retention. (b) β-catenin functions as a transcriptional coactivator in the Wnt signaling pathway. Cby antagonizes β-catenin signaling by preventing the interaction between β-catenin and the Tcf transcription factor enhancer and by mediating the formation of a stable β-catenin–Cby–14-3-3 tripartite complex that results in the nuclear export of β-catenin.