Table II.
Interventions Testing Program Compounds
| Compound | Concentration | Age of Treatment Initiation | Lifespan Effect Sex – Mean Effect* (p-value) | Description | Reference |
|---|---|---|---|---|---|
| Aspirin | 20 ppm | 4 months | M – 8% (p=0.001) F – ns |
Non-steroidal anti-inflammatory, anti-thrombotic, anti-oxidant | [1;2]† |
| Nitroflurbiprofen (NFP) | 200 ppm | 4 months | M – ns F – ns |
Nitric oxide releasing non-steroidal anti-inflammatory drug | [1;2]† |
| Nordihydroguaiaretic acid (NDGA) | 2,500 ppm | 9 months | M – 12% (p=0.006) F – ns |
Anti-oxidant, anti-inflammatory, polyphenol | [1;2]† |
| 4-OH-α-phenyl-tert-butylnitrone (4-OH-PBN) | 315 ppm | 4 months | M – ns F – ns |
Nitrone-based free radical trap | [1;2]† |
| Caffeic acid phenethyl ester (CAPE) | 30 ppm | 4 months | M – ns F – ns |
Anti-oxidant, anti-inflammatory, anti-tumorigenic | [3]† |
| Caffeic acid phenethyl ester (CAPE) | 300 ppm | 4 months | M – ns F – ns |
Anti-oxidant, anti-inflammatory, anti-tumorigenic | [3]† |
| Enalapril Maleate | 120 ppm | 4 months | M – ns F – ns |
Anti-hypertensive agent; Angiotensin converting enzyme inhibitor | [3]† |
| Rapamycin | 14 ppm | 20 months | M – 9% (p<0.0001) F – 13% (p<0.0001) |
Anti-fungal, anti-cancer, immunosuppressant | [3]† |
| Rapamycin | 14 ppm | 9 months | In testing | Anti-fungal, anti-cancer, immunosuppressant | [3]† |
| Simvastatin | 12 ppm | 10 months | In testing | Hypolipidemic drug | † |
| Simvastatin | 120 ppm | 10 months | In testing | Hypolipidemic drug | † |
| Resveratrol | 300 ppm | 12 months | In testing | Phytoalexin, anti-fungal, anti-microbial, anti-cancer, anti-inflammatory, polyphenol | † |
| Resveratrol | 1,200 ppm | 12 months | In testing | Phytoalexin, anti-fungal, anti-microbial, anti-cancer, anti-inflammatory, polyphenol | † |
| Resveratrol | 300 ppm | 4 months | In testing | Phytoalexin, anti-fungal, anti-microbial, anti-cancer, anti-inflammatory, polyphenol | † |
| Oxaloacetic acid | 2,200 ppm | 4 months | In testing | Citric acid cycle metabolite | † |
| Green Tea Extract | 2,000 ppm | 4 months | In testing | Anti-oxidant, anti-inflammatory, polyphenol(s), | † |
| Curcumin | 2,000 ppm | 4 months | In testing | Anti-tumor, anti-oxidant, anti-inflammatory, polyphenol | † |
| Medium Chain Triglyceride Oil | 60,000 ppm | 4 months | In testing | Fat supplement | † |
| 17α-Estradiol | 4.8 ppm | 10 months | In testing | Neuroprotective, mitochondrial protective, muscle relaxant | † |
| Methylene Blue | 28 ppm | 4 months | In testing | Chemical dye, diverse biological activities | † |
| Acarbose | 1,000 ppm | 4 months | In testing | Glycoside hydrolase inhibitor, anti-diabetic | † |
| Rapamycin LoPhase II | 4.7 ppm | 9 months | In testing | Anti-fungal, anti-cancer, immunosuppressant | † |
| Rapamycin MidPhase II | 14 ppm | 9 months | In testing | Anti-fungal, anti-cancer, immunosuppressant | † |
| Rapamycin HiPhase II | 42 ppm | 9 months | In testing | Anti-fungal, anti-cancer, immunosuppressant | † |
M=Male, F=Female; ns – not significant