Table 5. miRNAs in Alzheimer's disease.

miRNA group	Gray matter or white matter enriched	Upregulated or downregulated in Alzheimer's disease	miRNAs in group
A	Gray matter	Upregulated	miR-519e, miR-574-5p, miR-498, miR-518a-5p/miR-527, miR-525-5p, miR-300, miR-576-3p, miR-583, miR-146b-3p, miR-490-3p, miR-549, miR-516a-5p, miR-510, miR-184, miR-516b, miR-298, miR-214, miR-198, miR-451, miR-144, miR-424, let-7e
B	White matter	Upregulated	miR-509-5p, miR-574-3p, miR-576-5p, miR-302e, miR-220b, miR-208a, miR-215
C	Gray matter	Downregulated	miR-485-3p, miR-381, miR-124, miR-34a, miR-129-5p, miR-29a, miR-143, miR-136, miR-145, miR-138, miR-129-3p, miR-128, miR-379, miR-299-5p, miR-218, miR-149, miR-135a, miR-7, miR-126, miR-411, miR-335, miR-9, miR-378, miR-488, miR-432, miR-127-5p, miR-127-3p, miR-491-5p, miR-376c, miR-377, miR-95, miR-222, miR-29b, miR-329, miR-495, miR-551b, miR-195, miR-125b, miR-30b, miR-221, miR-139-5p, miR-487a, miR-487b, miR-107, miR-146b-5p, miR-29c, miR-30a, miR-582-5p, miR-103, miR-342-3p, miR-331-3p, miR-30c, miR-30d, miR-382, miR-22, miR-125a-5p
D	White matter	Downregulated	miR-491-3p, miR-423-5p, miR-34b, miR-422a, miR-34c-5p, miR-584, miR-219-5p, miR-338-3p, miR-219-2-3p, miR-338-5p, miR-181a, miR-181b, let-7b, miR-151-3p, miR-197, miR-19a, miR-20a, miR-17, miR-106a, miR-32, miR-340, miR-19b, miR-21, miR-151-5p, miR-194, let-7c, miR-330-3p, miR-27b, miR-93, miR-15a, miR-339-5p, miR-193b, miR-106b, miR-16, miR-23b, miR-15b, miR-320d, miR-320b, miR-320c, miR-320a, miR-557, miR-33a, let-7a, miR-374b, miR-140-3p, miR-374a, miR-24, miR-140-5p, miR-26a, miR-513a-5p, miR-212, miR-142-5p, miR-142-3p, miR-26b, miR-520d-5p, miR-193a-3p, miR-92b, miR-330-5p, miR-186, let-7f, miR-223, miR-412, miR-185, miR-148b, miR-101, miR-99b, miR-27a, miR-589, let-7i, miR-361-3p, miR-361-5p, miR-423-3p, miR-190, miR-301a, miR-365, miR-23a, miR-363, miR-326
E	Gray matter	Downregulated	miR-425, miR-191, miR-519d, let-7g, miR-98, miR-99a, miR-30e

Five groups of miRNAs (A–E) that were shown graphically on Fig. 4. miRNAs were grouped by the similarity of gene expression as detected across all nondegraded samples including both gray and white matter. As might be expected, some of the variability corresponded to whether the tissue was sampled from gray matter or white matter-Group D was almost exclusively white matter-enriched miRNAs, whereas Group C was mostly gray matter-enriched. MiRNAs that were positively correlated with the density of diffuse amyloid plaques (DPs) were in group A and B. By contrast, the negatively correlated miRNAs were in groups C–E. The complete gene expression data is provided in Supplemental Table 1