Table 1.
WT (10wks) | A1-TGind (10wks) | A1-TGind (26wks) | A1-TGcon (10wks) | |
---|---|---|---|---|
N | 8 | 10 | 6 | 5 |
HR (bpm) | 441 ± 16 | 316 ± 24** | 151 ± 7** | 162 ± 13** |
FS% | 46.5 ± 1.7 | 49.2 ± 2.6 | 29.7 ± 1.6* | 16.8 ± 4.7** |
LVEDD (mm) | 2.84 ± 0.11 | 3.18 ± 0.11 | 4.91 ± 0.24** | 4.91 ± 0.21** |
LVESD (mm) | 1.53 ± 0.08 | 1.64 ±0.13 | 3.45± 0.24** | 4.10 ± 0.36** |
Echocardiography of male wild type and mice constitutively expressing A1-AR (A1-TGcon) and after DOX was removed from their diet at 3 weeks to induce myocardial A1-AR expression (A1-TGind). Echocardiography data: HR, heart rate; FS%, percent fractional shortening; LVEDD, LV end-diastolic dimension in mm; LVESD, LV end-systolic dimension in mm. Values are means +/− SEM.
P<0.01 vs. WT and
P<0.001 vs. WT