Table I.
Baseline characteristics of 1221 women from the Nurses’ Health Study in 1990
| Cases (n=421) | Controls (n=800) | P-value | |
|---|---|---|---|
| Lp-PLA2 ng/mm/mL Mean (range) | 169.2 (50.3 – 292.0) | 153.7 (45.9 – 371.4) | <0.001 |
| Age, (mean years) | 59.9 | 59.9 | -- |
| Current smoking, % | 27 | 27 | -- |
| BMI, (mean kg/m2) | 26.7 | 25.1 | <0.001 |
| Postmenopausal Hormone use, % | 35 | 38 | 0.27 |
| Family history of MI, % | 21 | 12 | <0.001 |
| History of hypertension, % | 50 | 27 | <0.001 |
| History of hypercholesterolemia, % | 53 | 41 | <0.001 |
| History of diabetes, % | 14 | 6 | <0.001 |
| Cholesterol medication use % | 4 | 3 | 0.08 |
| LDL (mean mg/dl) | 144.1 | 136.1 | <0.001 |
| HDL (mean mg/dl) | 52.3 | 60.0 | <0.001 |
| Triglycerides (median mg/dl)* | 126.0 | 99.0 | <0.001 |
| HbA1c (%) | 5.9 | 5.5 | <0.001 |
| CRP (median mg/L) | 2.6 | 2.0 | 0.01 |
| ICAM (median ng/mL)† | 293.0 | 279.0 | 0.08 |
| Physical activity (mean MET-hr/wk) | 18.5 | 19.2 | 0.60 |
| Alcohol (mean g/day) | 4.8 | 6.2 | 0.02 |
Abbreviations: n, Number of Participants
*
293 cases and 534 controls have fasting triglyceride measurements
†
253 cases and 422 controls have ICAM measurements